Bagaimana jika manusia meninggalkan planet Bumi dan seseorang lupa menon-aktifkan robot miliknya?
Wall-E, menghabiskan hari-harinya melakukan hal-hal yang memang ia diciptakan untuk itu. Namun dengan cepat Wall-E tersadar mengapa ia diciptakan, sebagaimana petualangannya melintasi galaksi untuk mengejar mimpinya
In a distant, but not so unrealistic future, where mankind has abandoned earth because it has become covered with trash from products sold by the powerful multi-national Buy N Large corporation, WALL-E, a garbage collecting robot has been left to clean up the mess. Mesmerized with trinkets of earth's history and show tunes, WALL-E is alone on Earth except for a sprightly pet cockroach. One day, Eve, a sleek (and dangerous) reconnaissance robot, is sent to earth to find proof that life is once again sustainable. WALL-E falls in love with Eve. WALL-E rescues Eve from a dust storm and shows her a living plant he found amongst the rubble. Consistent with her "directive" Eve takes the plant and automatically enters a deactivated state except for a blinking green beacon. WALL-E, doesn't understand what has happened to his new friend, but true to his love, he protects her from wind, rain, and lightening, even as she is unresponsive. One day a massive ship comes to reclaim Eve, but WALL-E, out of love or loneliness hitches a ride on the outside of the ship to rescue Eve. The ship arrives back at a large space cruise ship, which is carrying all of the humans who evacuated earth 700 years earlier. The people of earth ride around this space resort on hovering chairs which give them a constant feed of TV and video chatting.